Clinical Research Excellence Award Archives

🏛️Early Academic Pursuits

Tiepeng Wang earned his BSc in Life Sciences from Jilin University in 2002 and his Ph.D. from the Institute of Biophysics, Chinese Academy of Sciences, in 2007. His early career involved serving as a research assistant and postdoc at the Institute of Biophysics and Neurosciences, where he laid the foundation for his future research in neurodegenerative diseases and redox regulation mechanisms.

Since 2011, Tiepeng Wang has been an associate professor at Shihezi University’s Medical School and a Special Research Assistant at the Institute of Biophysics since 2021. His career is marked by leading multiple research projects funded by prestigious institutions, including the National Natural Science Foundation of China and the Science and Technology Program of Xinjiang Production and Construction Corps. He has published over 20 research papers and edited several textbooks, significantly contributing to the academic community.

Discovery of Necroptosis in Neurodegenerative Diseases: By integrating cellular biology, biochemistry, bioinformatics, and animal behaviorology, Tiepeng Wang discovered that nitric oxide (NO) and necroptosis are the primary pathways leading to neuronal damage in diseases such as Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis. His research indicated that as the severity of these diseases increases, neuronal death pathways shift towards necroptosis.
Neuroprotective Effects of GSNOR: His studies identified the enzyme GSNOR as having significant neuroprotective effects against neurotoxicity. He proposed combining creatine with GSNOR to enhance neuroprotection, addressing the limitations of using creatine alone in clinical trials.

Tiepeng Wang’s research has had a profound impact on understanding the mechanisms of neuronal damage and developing potential therapeutic strategies for neurodegenerative diseases. His work on NO and necroptosis has opened new avenues for drug development, targeting necroptosis to mitigate neuronal damage.

Young Member, Free Radical Biology and Free Radical Medicine Professional Committee, Chinese Society for Biophysics

Member, Chinese Society for Cell Biology

Member, Chinese Society for Neuroscience

Notable Collaborations:

National Key R&D Program of China (2022YFA1303000): Collaboration with Prof. Chen Chang, focusing on maintenance of redox homeostasis and stress intervention.

National Natural Science Foundation of China (81360142): Collaboration with Prof. Xie Jianxin on the impact of obesity on bone metabolism.

National Key Basic Research Program of China (2005CB522804): Collaboration with Prof. Chen Chang on cognitive brain imaging and visual invariance.

By consistently pushing the frontiers of biomedical research, Tiepeng Wang continues to pave the way for new therapeutic strategies and a deeper understanding of neurodegenerative diseases. His work not only advances scientific knowledge but also holds the promise of improving clinical outcomes for patients worldwide.

Tiepeng Wang’s legacy in the field of biophysics and neuroscience is marked by his significant discoveries and innovative research approaches. His ongoing projects and collaborations, such as the National Key R&D Program of China on redox homeostasis and stress intervention, continue to push the boundaries of our understanding of neuronal health. As a young member of the Free Radical Biology and Free Radical Medicine Professional Committee of the Chinese Society for Biophysics, and as a member of both the Chinese Society for Cell Biology and the Chinese Society for Neuroscience, Tiepeng Wang is poised to make enduring contributions to science and medicine.

Optimization of a glutamate excitotoxicity model in cultured cerebellar granule neurons
- Authors: Wang, T.-P., Zhang, T., Chen, C.
- Journal: Progress in Biochemistry and Biophysics, 2013, 40(8), pp. 775–782
Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila
- Authors: Hou, Q., Jiang, H., Zhang, X., Liu, L., Chen, C.
- Journal: Nitric Oxide – Biology and Chemistry, 2011, 24(1), pp. 17–24
A novel mechanism underlying the susceptibility of neuronal cells to nitric oxide: The occurrence and regulation of protein S-nitrosylation is the checkpoint
- Authors: He, J., Wang, T., Wang, P., Yin, Q., Chen, C.
- Journal: Journal of Neurochemistry, 2007, 102(6), pp. 1863–1874
Activation of GSNOR transcription by NF-κB negatively regulates NGF-induced PC12 differentiation
- Authors: Wu, K., Zhang, Y., Wang, P., Wang, T., Chen, C.
- Journal: Free Radical Research, 2014, 48(9), pp. 1011–1017