Xiang Li | Epigenetics | Best Researcher Award

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Prof. Xiang Li | Epigenetics |Best Researcher Award

International Collaboration:
  • His involvement in both national research grants in China and Australia, including the prestigious Early Career Researcher Grant from the Australian Academy of Science, underscores his global contribution to neuroscience research.
 Prof. Xiang Li, Wuhan University , China

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🏛️Early Academic Pursuits

  • Xiang Li began his academic journey in the realm of epigenetics and cognitive neuroscience. His foundational work laid a strong focus on the neural and epigenetic mechanisms underlying memory, especially fear memory. Early in his career, he worked on deciphering the complex relationship between gene expression and cognitive function, laying the groundwork for his later breakthroughs in neurological research.

👨‍🔬 PROFESSIONAL ENDEAVORS

  • As a Professor at Wuhan University, Xiang Li has built a distinguished career dedicated to unraveling the epigenetic and cognitive processes in fear memory. His groundbreaking research has led to significant advancements in understanding fear-related psychiatric disorders and developing targeted treatments. Notably, Li has successfully completed or is currently involved in projects such as Neuronepigenetics during the Fear Condition and Fear Extinction Learning, and Multimodal Single-Cell Profiling of Human and Mouse Prefrontal Neuron Subregions.

🧬 RESEARCH FOCUS

  • Nucleic Acid Modifications in Cognitive Function – His research sheds light on how nucleic acid modifications affect cognitive functions, particularly memory.
  • Epigenetic Regulation in Neurological and Cerebrovascular Diseases – Li focuses on circular DNA/RNA’s role in regulating neuroimmune responses and neurodevelopment.
  • Whole-Genome Detection Technologies – Xiang Li has pioneered techniques in epigenetics, pushing forward new technologies to detect changes across the genome, particularly related to memory formation and psychiatric disorders.

🏆 CONTRIBUTIONS AND AWARDS

  • Xiang Li’s contributions extend beyond his publications. His leadership in the field has been acknowledged with prestigious research grants in both Australia and China, including the Early Career Researcher Grant from the Australian Academy of Science. In 2019, he was honored with the Mark Rower Award from the Australian Neuroscience Society. Additionally, he has been selected for the Hubei Province “100 Talent Plan”, further recognizing his outstanding contributions to neuroscience.

📊 IMPACT AND INFLUENCE

  • Professor Xiang Li’s work has gained widespread recognition in the academic world. His research publications have amassed an impressive 1,895 citations, with an h-index of 22 and an i10-index of 34. Over the past five years, he has published more than 20 papers in highly respected journals such as Nature Neuroscience, Biological Psychiatry, PNAS, and the Journal of Neuroscience, contributing a cumulative impact factor exceeding 120. Two of his papers have been selected by F1000 as must-read articles, further cementing his influence in the neuroscience community.

🏅ACADEMIC CITES

  • His work is widely referenced by scholars in the fields of neuroscience and cognitive research. With nearly 1,900 citations and a high h-index, his contributions are shaping the current understanding of memory-related psychiatric disorders. His work is pivotal in advancing therapeutic strategies that target cognitive and fear memory disorders.

🚀 LEGACY AND FUTURE CONTRIBUTIONS

  • Looking ahead, Xiang Li’s research will continue to play a key role in uncovering the mechanisms that link epigenetics with cognitive neuroscience. His future work promises to further explore epigenetic regulatory mechanisms in neuroimmune cells and their role in cognitive function. His ongoing projects on whole-genome detection technology will likely yield new insights into neurological diseases, pushing the frontiers of both clinical and theoretical neuroscience.

📰PUBLICATIONS

  • Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders
    Authors: KJ Dudley, X Li, MS Kobor, TE Kippin, TW Bredy
    Journal: Neuroscience & Biobehavioral Reviews 35 (7), 1544-1551
  • The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
    Authors: Q Lin, W Wei, CM Coelho, X Li, D Baker-Andresen, K Dudley, VS Ratnu, …
    Journal: Nature Neuroscience 14 (9), 1115-1117
  • Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation
    Authors: X Li, W Wei, QY Zhao, J Widagdo, D Baker-Andresen, CR Flavell, …
    Journal: Proceedings of the National Academy of Sciences 111 (19), 7120-7125
  • Activation of BDNF signaling prevents the return of fear in female mice
    Authors: D Baker-Andresen, CR Flavell, X Li, TW Bredy
    Journal: Learning & Memory 20 (5), 237-240
  • p300/CBP-associated factor selectively regulates the extinction of conditioned fear
    Authors: W Wei, CM Coelho, X Li, R Marek, S Yan, S Anderson, D Meyers, …
    Journal: Journal of Neuroscience 32 (35), 11930-11941

Zhiyu Liu | Methylation | Best Researcher Award

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Ms. Zhiyu Liu | Methylation | Best Researcher Award

Innovative Research:

Her work on the determination of cfDNA methylation by Methylation-Sensitive High-Resolution Melting (MS-HRM) is innovative, offering potential new diagnostic tools for gestational diabetes mellitus. Additionally, her analysis of genome-wide cfDNA methylation presents significant progress in understanding epigenetic changes, which are critical in disease diagnosis and treatment.

Ms. Zhiyu Liu ,Southeast University  , China

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🎓Early Academic Pursuits

Zhiyu Liu’s academic journey began with a robust foundation in animal medicine at Nanjing Agricultural University. During her undergraduate years, she displayed an exceptional aptitude for understanding complex biological processes, which fueled her passion for further exploration in the field of toxicology at the master’s level. Her early academic endeavors laid the groundwork for her future specialization in biomedical engineering, particularly focusing on the nuances of RNA and DNA methylation.

👩‍🔬Professional Endeavors

Pursuing a Ph.D. at Southeast University, Liu has immersed herself in cutting-edge research in biomedical engineering. Her work primarily revolves around RNA methylation and DNA methylation, where she explores the epigenetic modifications that play critical roles in various diseases. Her studies are pivotal in advancing the understanding of molecular biology and have significant implications for diagnostic and therapeutic strategies.

🔬 CONTRIBUTIONS AND RESEARCH FOCUS

  • Liu’s research contributions are highlighted by her innovative studies on cell-free DNA methylation and RNA sequencing. Her work on the impact of blood sample processing on RNA sequencing and her pioneering approach to using Methylation-Sensitive High-Resolution Melting (MS-HRM) for diagnosing gestational diabetes mellitus (GDM) have been particularly influential. These contributions have not only broadened the scientific community’s understanding of epigenetics but also opened new avenues for diagnostic methodologies.

🌍Impact and Influence

  • Liu’s publications in reputable journals like Analytical Letters, Genes, and Analyst have garnered significant attention in the scientific community. Her research on genome-wide cell-free DNA methylation has been instrumental in shaping current and future studies in the field. The influence of her work is evident in the citations her research has received, reflecting the impact of her findings on ongoing research and applications in biomedical sciences.

🏅ACADEMIC CITES AND RECOGNITION

Liu’s work has been widely recognized for its academic rigor and innovative approach. Her publications have been cited by numerous researchers, underscoring the relevance and importance of her contributions to the field of biomedical engineering. The citation of her work in subsequent studies highlights the foundational nature of her research in advancing the understanding of RNA and DNA methylation.

🌍 LEGACY AND FUTURE CONTRIBUTIONS

Zhiyu Liu’s work in the fields of RNA and DNA methylation, as well as her contributions to toxicology, are paving the way for future research and innovation. Her studies on cfDNA methylation have potential applications in the diagnosis of diseases such as gestational diabetes mellitus, highlighting the clinical relevance of her research. With her active and diligent approach to scientific inquiry, Zhiyu is poised to make lasting contributions to the field of biomedical engineering. Her strong teamwork spirit, coupled with her ability to handle work pressure and solve complex problems, will undoubtedly lead to significant advancements in understanding and treating diseases through molecular biology.

📰PUBLICATIONS

  • Tandem Guest-Host-Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus
    Authors: Zhan, W., Xu, L., Liu, Z., … Yu, Q., Liang, G.
    Journal: Angewandte Chemie – International Edition, 2023, 62(32), e202306427
  • Enzymatic Self-Assembly of Adamantane-Peptide Conjugate for Combating Staphylococcus aureus Infection
    Authors: Zhan, W., Gao, G., Liu, Z., … Sun, X., Liang, G.
    Journal: Advanced Healthcare Materials, 2023, 12(18), 2203283
  • Single-cell Multi-omics Sequencing and Its Application in Tumor Heterogeneity
    Authors: Sun, Y., Liu, Z., Fu, Y., … Bai, Y., Ge, Q.
    Journal: Briefings in Functional Genomics, 2023, 22(4), pp. 313–328
  • Spatial Transcriptome Profiling of Mouse Hippocampal Single Cell Microzone in Parkinson’s Disease
    Authors: Jia, E., Sheng, Y., Shi, H., … Zhao, X., Ge, Q.
    Journal: International Journal of Molecular Sciences, 2023, 24(3), 1810
  • Analysis Approaches for the Identification and Prediction of N6-methyladenosine Sites
    Authors: Yang, Y., Liu, Z., Lu, J., … Xie, X., Ge, Q.
    Journal: Epigenetics, 2023, 18(1), 2158284