Prof.Dr Qingchun Zeng | Calcific Aortic Valve Disease |  Best Researcher Award

Prof Dr. Qingchun Zeng , Southern Medical University, China

Professional Profile


Academic and Professional Background 📘

Dr. Zeng Qingchun has dedicated his career to understanding and combating the pathogenesis, prevention, and treatment of calcific aortic valve disease (CAVD) and heart failure. His research delves into the role of immune regulation in these conditions, exploring the molecular pharmacological effects and mechanisms. He has pioneered several fundamental theories on the involvement of intestinal flora and metabolites in the pathogenesis of CAVD.

 Research and Innovations 🧪📊

  • Completed/Ongoing Research Projects: Dr. Zeng has spearheaded numerous research projects, including four funded by the National Natural Science Foundation (Project Nos: 82270374, 82070403, B17703BG, 815703SZ).
  • Citation Index: Scopus Profile
  • Consultancy/Industry Projects: None


Dr. Zeng has published 295 articles in prominent journals. Notable publications include:

  1. Xiang G, Huang R, Xie M, Zhao H, Xu X, Chen Y, Ren H, Nu D, Feng B. Non-coding RNA regulates the expression of KRM1 and DKK1 to synergistically affect aortic valve lesions. Exp Mol Med. 2024. DOI: 10.1038/s12276-024-01256-5
  2. Zhong G, Su S, Li J, Zhao H, Hu D, Chen J, Li S, Lin Y, Wen L, Lin X, Xiang G, Xu D, Zeng Q. Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cells through YAP-dependent mechanotransduction. Sci Adv. 2023. DOI: 10.1126/sciadv.adg0478
  3. Li S, Luo Z, Su S, Lin L, Xiang G, Zhao J, Xu X, Xu D, Zeng Q. Targeted inhibition of PTPN22 alleviates osteogenic responses in aortic valve interstitial cells and lesions in mice. BMC Med. 2023. DOI: 10.1186/s12916-023-02888-6
  4. Peng X, Su S, Zeng J, Xie K, Yang X, Xiang G, Xiao Z, Zhu P, Zeng S, Xu D, Zeng Q. 4-Octyl itaconate suppresses osteogenic response in aortic valvular interstitial cells via the JAK2/STAT3 pathway. Free Radic Biol Med. 2022. DOI: 10.1016/j.freeradbiomed.2022.06.246
  5. Meng Q, Liu C, Ao L, Cleveland JC Jr, Song R, Xu D, Fullerton DA, Meng X. Cross-talk between the TLR4 and Notch1 pathways augments the inflammatory response in the interstitial cells of stenotic human aortic valves. Circulation. 2012. DOI: 10.1161/CIRCULATIONAHA.111.083675

 Editorial Appointments📝

  • Cardiovascular Innovation and Applications, Editorial Board Member
  • Frontiers in Cell and Developmental Biology, Guest Editor
  • Frontiers in Cardiovascular Medicine, Senior Editor
  • Journal of Molecular and Cellular Cardiology, Editorial Board Member

Collaborations 🤝

Dr. Zeng leads international defense and technology cooperation projects in Guangdong Province, including research on the mechanisms by which Hesperetin prevents cardiovascular disease and mitigates mitochondrial damage.

Professional Memberships 🏅

  • Standing Committee, Heart Failure Committee of Guangdong Medical Association
  • Member, Atherosclerosis Professional Committee of Chinese Pathophysiological Society
  • Member, China Branch of the International Atherosclerosis Society
  • Member, Expert Committee of the Heart Failure Specialist Medical Association

Areas of Research 🔬

  • Calcific Aortic Valve Disease
  • Heart Failure


Dr. Zeng’s extensive research, published in top-tier international journals, has significantly advanced understanding of the increasing incidence and pathogenesis of CAVD. His clinical studies and data analyses provide crucial evidence for transcatheter treatments, antithrombotic programs, and prognosis assessment, thereby enhancing clinical diagnosis and treatment of CAVD.

    • α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice
      • Journal: Molecular Medicine
      • Authors: Yu, H., Gan, D., Luo, Z., Xu, D., Ren, H.
      • Year: 2024
      • Citations: 4
    • Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone: Insights from TOPCAT
      • Journal: Chinese Medical Journal
      • Authors: Lin, Y., Zhao, H., Hu, D., Xu, D., Zeng, Q.
      • Year: 2024
      • Citations: 0
    • Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study
      • Journal: Cardiovascular Innovations and Applications
      • Authors: Chen, J., Lin, Y., Teng, Z., Li, J., Zeng, Q.
      • Year: 2024
      • Citations: 0
    • Targeted inhibition of PTPN22 is a novel approach to alleviate osteogenic responses in aortic valve interstitial cells and aortic valve lesions in mice
      • Journal: BMC Medicine
      • Authors: Li, S., Luo, Z., Su, S., Xu, D., Zeng, Q.
      • Year: 2023
      • Citations: 1
    • Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey
      • Journal: BMC Cardiovascular Disorders
      • Authors: Yang, X., Zhou, H., Zhang, H., Xu, D., Zeng, Q.
      • Year: 2023
      • Citations: 3
Prof Dr. Qingchun Zeng | Calcific Aortic Valve Disease | Best Researcher Award | 1131